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Adrenaline from vigorous exercise can shrink tumours by up to 50%

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exercise1ALTHOUGH exercising while undergoing treatment for cancer is the last thing many sufferers feel like doing, it could have hugely beneficial side-effects in the long-term.

Researchers studying tumours in mice have discovered that intensive physical activity can help the body’s own defences shrink the growths by up to a staggering 50 per cent.

The research was published in Cell Metabolism.

Although this particular study was carried out in animals, researchers claim the findings suggests higher intensity workouts may be of a similar benefit to human cancer patients.

The study was carried out by researchers at the University of Copenhagen, Denmark. They put a group of mice with lung tumours on exercise wheels, while a separate, control group of mice with cancer were not given any exercise.

The mice who spent time running on the wheel shrunk their tumours by 50 per cent compared to their less active counterparts.
‘Natural Killer’ cells were directed towards tumours during vigorous exercise, the research published in Cell Metabolism found.

In particular, researchers believe that the shot of adrenaline produced by a high-intensity workout helps move these immune cells towards lung, liver, or skin tumours.

Exercise for many cancer patients may be difficult because of their illness. The recommended amount of exercise for healthy adults is 150 minutes of moderate intensity exercise a week.

Macmillan Cancer Care recommends cancer patients who are unable to achieve this amount should be as active as their abilities and condition permits them to be.

A 2012 study by Macmillan found 77 per cent of cancer patients had not received any advice from their physicians on the benefits of exercise.

A review of six studies by Macmillan found 150 minutes of moderate-intensity activity per week had a 40 per cent lower risk of breast cancer morality, and breast cancer recurrence compared with women active for less than one hour per week.

Colorectal cancer was reduced by 50 per cent in patients who managed the equivalent of six hours of moderate intensity activity per week.

Pernille Hojman, of the University of Copenhagen said of the research: “It is known that infiltration of natural killer (NK) immune cells can control and regulate the size of tumours, but nobody had looked at how exercise regulates the system.

“In our experiments, we tried to inject our mice with adrenaline to mimic this increase you see during exercise, and when we do that we see that the NK cells are mobilised to the bloodstream, and if there’s a tumour present then the NK cells will find the tumour and home to it.”

Mice on the running wheel with reduced numbers of ‘natural killer’ cells did not show a reduction in tumour size.

Blocking the effect of adrenaline had a similar effect, leading the researchers to conclude that adrenaline must be interacting with the natural killer cells.

The researchers also found that a chemical signal produced by muscles during exercise, Interleukin 6 (IL-6), helps guide natural killer cells towards tumour cells which Hojman said ‘was actually a big surprise to us.’

She added: “In this study we show that the exercise-induced IL-6 seems to play a role in homing of NK cells to the tumour and also in the activation of those NK cells.”

Further research will be needed to show that exercise may have beneficial effects on cancer patients.

“As someone working in the field of exercise and oncology, one of the main questions that cancer patients always ask is: how should I exercise?,” asked Dr Hojman.

While it has previously been difficult to advise people about the intensity at which they should exercise, our data suggest that it might be beneficial to exercise at a somewhat high intensity in order to provoke a good epinephrine [adrenaline] surge and hence recruitment of NK cells.”

*Culled from DailyMailUK online



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