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Drinking causes tumour by permanently damaging genes, breaking up DNA

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Drinking alcohol has been found to damage Deoxy ribonucleic Acid (DNA)/genetic material – causing an increased chance of breast cancer and other major types of the disease.

Now researchers have found for the first time ‘a simple plausible explanation’ of why alcohol can causes our cells to go haywire – by causing damage to our DNA.

The breakthrough is claimed to explain how seven types of tumours form, including those of the mouth and throat, liver, colon, bowel and breast.When alcohol is broken down in the body it forms a poisonous chemical, known as acetaldehyde.Small amounts can be mopped up by our bodies. Yet too much damages stem cells in our bodies – the ‘master cells’ which generate new cells. This raises the risk they will go rogue and form cancerous tumours.

It has been estimated almost six per cent of all cancer deaths worldwide could be attributed to alcohol.In the United Kingdom (UK), booze is linked to 12,800 cases of cancer – four per cent of total cancer cases.Of these, 3,200 cases of breast cancer are caused by alcohol, according to Cancer Research UK.

Heavy drinkers face a greater risk of mouth and throat cancer, cancer of the voice box, liver and colorectal cancers.The latest study, published in Nature, used mice to show how alcohol exposure led to irreparable genetic damage in stem cell DNA.A team at the Medical Research Council Laboratory of Molecular Biology, Cambridge, gave diluted alcohol – chemically known as ethanol – to mice.

They analysed the DNA in the mice to examine the damage caused by acetaldehyde.Acetaldehyde has long been known to be cancer-causing. But the mechanism by which it works was unclear.

The researchers found acetaldehyde breaks and damage DNA within blood stem cells, permanently altering their sequences within cells.The chemical causes breaks in both strands of the DNA ‘double helix’ making them become jumbled up.

Alcohol is not thought to cause blood cancers, however, the same mechanism is believed to apply to stem cells in other organs of the body.Lead author Professor Ketan Patel said: “Some cancers develop due to DNA damage in stem cells. While some damage occurs by chance, our findings suggest that drinking alcohol can increase the risk of this damage.”

The body can dispose of acetaldehyde by producing enzymes that break the chemical down.Another protective mechanism is a variety of DNA repair systems which, most of the time, allow them to fix and reverse different types of damage.

But there are limits to how much damage can be repaired and in some people the repair process is faulty.Patel said: “Our study highlights that not being able to process alcohol effectively can lead to an even higher risk of alcohol-related DNA damage and therefore certain cancers.

“But it’s important to remember alcohol clearance and DNA repair systems are not perfect and alcohol can still cause cancer in different ways – even in people whose defence mechanisms are intact.”


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