Former Lille striker Origi, who has played for only 17 minutes in the league this season, started in the absence of Danny Ings, who has sustained a knee ligament injury, and Daniel Sturridge, who was left out of the squad.
In total Klopp made only two changes to the last team selected by his sacked predecessor Brendan Rodgers, with Origi and Adam Lallana replacing Ings and Sturridge.
Klopp, formerly of Borussia Dortmund, was also without captain Jordan Henderson, defender Joe Gomez and close-season signings Christian Benteke and Roberto Firmino due to injury.
The German has been brought in to revive the fortunes of a team who finished sixth in the league last season and who have won only once inside 90 minutes in their last nine games.
Klopp’s first Liverpool team: Mignolet; Clyne, Skrtel, Sakho, Moreno; Can, Lucas; Milner, Lallana, Coutinho; Origi
