Boluwatife Olu Afolabi: Bridging science and innovation in head, neck cancer research

In the very complex world of cancer research, some of the most significant breakthroughs often emerge from unexpected places. Dr. Boluwatife Olu Afolabi, a Nigerian clinician-scientist at the University of Minnesota, Twin Cities, has come to exemplify this truism through his innovative work in oral and craniofacial sciences. By reaching deep into the chemical foundations of head and neck cancers, he has begun to uncover crucial insights that could reshape the approach of scientists to head and neck cancer prevention and treatment.

“I believe the most important breakthroughs come not just from understanding cancer as a disease in the laboratory, but also from understanding that cancer is always linked to a human story. It’s important that we don’t simply see cancer as mere cellular mutations but rather as a chapter in someone’s life story.”

Growing up in Ado-Ekiti, Afolabi’s academic journey began at the prestigious College of Medicine, University of Ibadan. As a student, his early research endeavours demonstrated a keen interest in pressing medical challenges, such as the investigation of cervicofacial necrotising fasciitis in Africa and a publication on radiation safety in dentistry which was published in the DENTISCOPE Journal. The recognition of his potential came early, when he was awarded both the Nigerian Federal Government Scholarship and the coveted Agbami Scholarship for academic excellence supporting his studies.

In 2023, Afolabi was selected for the Clinical and Translational Science Institute (CTSI) Fellowship at the University of Minnesota, which marked a significant milestone in his career. Working alongside Dr. Irina Stepanov, a Distinguished McKnight University Professor and Mayo Professor in Public Health, he conducted pioneering research on Areca Nut and Gutkha commercial products, employing sophisticated Liquid Chromatography–High Resolution Mass Spectrometry (LC-HRMS) with electrospray ionisation. This led to the identification of approximately 149 previously unknown chemical constituents which may cause oral cancer, substantially advancing our understanding of these substances.

The Scientist Beyond the Laboratory

Afolabi’s impact extends well beyond his laboratory achievements. As a 2024 Guest Lecturer at the University of Minnesota’s Osher Lifelong Learning Institute, he demonstrates a commitment to sharing knowledge and engaging with the broader community. His intellectual reach spans beyond science; as an accomplished essayist, he masterfully weaves together scientific insight with broader and consequential societal themes. This literary talent earned him a shortlisting for the Babishai Niwe African Prize for Poetry in 2018, a testament to his ability to bridge the gap between scientific rigour and creative expression.

“Science and poetry are two languages telling the same human story. In my research, I see data points and molecular pathways, but in my writing, I see the rhythms and metaphors of life itself. When we bring these perspectives together, we create a fuller understanding of who we are and what we’re fighting for. That’s what drives me: the belief that the most profound discoveries happen when we dare to look at old problems through new lenses.”

Looking ahead, Afolabi’s research aims to unravel the complex relationships between specific carcinogens like those found in tobacco and cancer development, with a particular focus on understanding the pathways that drive cancer initiation and proliferation in the head and neck area. In the big picture, he hopes to bridge a crucial gap between laboratory discoveries and practical clinical applications, especially in identifying and mitigating cancer-causing agents. As a forward-looking Nigerian dentist-scientist, Afolabi represents a new generation of researchers poised to make significant contributions to cancer research and prevention on both sides of the Atlantic. His work not only advances scientific knowledge but also strengthens the bond between American and African medical research communities.

For those interested in following Dr. Boluwatife Olu Afolabi’s innovative work in oral and craniofacial sciences or translational research, connect with him on Twitter (@oluafolabi) or LinkedIn (linkedin.com/in/oluafolabi).