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Detoxification boosts fertility in couples undergoing IVF

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Detoxification

Nigerian researchers have demonstrated how supervised modern Mayr type of detoxification may positively affect fertility indices in infertile couples who undergo assisted reproductive technology (ART)/In Vitro Fertilisation (IVF).

The study was published in the journal Global Reproductive Health, however, concluded that there is need for further studies on larger populations to establish pattern of response further and more published data on this process should be encouraged as this may even demonstrate an overall advantage of such an approach in dealing with environmental toxins and other occupational hazards.

Modern Mayr Medicine detoxification is based on the different processes by which toxic substances are eliminated from the body and thorough intestinal cleansing is achieved for a healthy digestive system.

Emphasis is placed on rest and proper hydration, simplified alkaline diet with bias for individual food sensitivities and intolerances determined by bioenergetics resonance testing, use of orthomolecular supplements, therapeutic equipment for optimization of normal human physiology, and regular and supervised physical exercise.

Bioenergetics’ testing applies the knowledge of the biology of energy transformations and energy exchanges within and between living things and their environment to identify deficiencies and intolerances, a useful tool in pre-detoxification evaluation.

Oladapo A. Ashiru, Tinuke O. Adeyi, Ebele C. Iloabachie, Bolanle E. Bello, Chizara C. Okeke, and Ajibola V. Soyoye, conducted the study titled “Managing environmental exposure in clinical practice.”

Prof. Oladapo Ashiru, the Chief Medical Director (CMD), Mart Group of Health Services, which includes the Medical Art Center, Martlife Detox Clinic and Mart Medicare, Maryland Lagos, is the leader of the team of researchers.

Ashiru, who is also the Joint Pioneer of IVF in Nigeria and President African Fertility Society (AFS), told The Guardian: “Today, it is recommended that before attempting conception, these toxins should be removed from the body to avoid problems of infertility and miscarriage or abnormality in the baby. Mayr therapy as practiced in Martlife Detox Clinic in Lagos offers such therapy opportunities.”

Until now, several studies have shown that environmental toxins from various occupational industries like oil and gas, petrochemical, agriculture, and bad eating habits cause serious health hazards. This study describes the clinical success of Modern Mayr therapy type of detoxification in a fertility practice that uses detoxification as a complementary treatment.

According to the study, patient recruitment, Mayr therapy detoxification, and IVF procedures Mayr therapy-IVF cycles were performed for 218 patients. All cycles took place between January 2014 and December 2017 in collaboration between Medical Art Center (MART), Lagos, and Mart-life Detox Clinic, a Modern Mayr therapy center in Lagos.

Inclusion criteria were history of infertility of two years or more, one or more repeated IVF failures, recurrent pregnancy loss, and body mass index (BMI) greater 27 kg/m2 (weight in kilogrammes/height in metres square).

Patients were divided into two groups, A and B. Group A included 131 patients who had one or more previous failed IVF cycles at MART before Mayr therapy. Group B included 87 patients with no prior IVF procedure at MART before Mayr therapy. Both groups contained patients who used their own oocytes and those who used donor oocytes

All the couples underwent the basic fertility work-up (blood screening, clinical examination, semen analysis, trans-vaginal ultra- sound scan, day-three female hormonal profile, hysterosalpingography) at MART.

Hysterosalpingography, also called uterosalpingography, is an x-ray examination of a woman’s uterus and fallopian tubes that uses a special form of x-ray called fluoroscopy and a contrast material. An x-ray (radiograph) is a noninvasive medical test that helps physicians diagnose and treat medical conditions.

All couples also received, signed and returned necessary consent forms. Mayr-type detoxification therapy at Mart-life Detox clinic was carried out with protocols using special dietary nutrition, equipment such as the hypoxicator which improves cellular mitochondrial function, colon hydrotherapy to help flush out intestinal waste. Physiotherm, Steam baths, and Sauna were used to improve general circulation, the sea-oxygenator to aid cellular rejuvenation, and the lymphodrainer to enhance proper lymphatic drainage.

In addition, each person was placed on a customized diet that took into account individual intolerances.

After Mayr detoxification, IVF cycles commenced following standard IVF protocols in combination with micromanipulation techniques for intra-cytoplasmic sperm injection (ICSI) previously described in other studies. Controlled ovarian stimulation using gonadotrophin-releasing hormone agonist (short or long) or gonadotrophin- releasing hormone antagonist protocols and follicle-stimulating hormone was initiated.

Patients and donors were monitored regularly by ultrasound scans and hormone tests. Transvaginal ultrasound–guided oocyte pick up was scheduled for 36 hours after the administration of human chorionic gonadotrophin injection as reported previously.

The results showed 89 percent of all patients achieved significant weight reduction and improvement in BMI. The mean ages of the women were slightly similar in both groups. From a total of 131 patients placed in group A, 74 used their own oocytes and 57 used donor oocytes.

The mean patient age was 37.16 and 45.9 years, respectively. For all patients who used their oocytes, 108 oocytes were retrieved from the last cycle before detoxification and 207 oocytes after detoxification.

Ten of the 74 patients were identified as poor responders based on their previous IVF cycles. In this subset, there was a substantial increase in the total number of oocytes retrieved after detoxification.

Twenty-seven oocytes from their last cycle before and 80 oocytes after Mayr therapy. Overall positive hCG rate in group A was 41.2 per cent with clinical pregnancy rate of 27.5 per cent and live birth rate of 23.7 per cent. There are five ongoing pregnancies.

According to the study, of the 87 patients placed in group B, 43 patients used their own oocytes and 44 used donor oocytes. The mean patient age was 37.7 and 43.5 years, respectively. Overall, positive Human chorionic gonadotropin (hCG) rate in this group was 31 per cent with clinical pregnancy rate of 21.8 per cent and live birth rate of 15 per cent.

hCG is a hormone produced by the placenta after implantation.

There are currently six ongoing gestations. Patients with own oocytes had a pregnancy rate of 30.2 per cent, clinical pregnancy rate of 20.9 per cent and live birth rate of 16.3 per cent. Patients using donor oocytes had pregnancy rate of 31.8 per cent, clinical pregnancy rate of 22.7 per cent, and live birth rate of 13.6 per cent.

Ashiru further explained: “Many couples that are unable to achieve pregnancy suffer from a combination of subclinical conditions, which may stem from long- term exposure to various environmental toxins. Such exposure to environmental toxins (in the form of industrial chemicals) both in utero and in the neonatal period may dramatically affect adult fertility. Environmental toxins that can alter hormone function are known as endocrine disruptors.

The strongest evidence of heavy metals and environmental pollution adversely interfering with healthy reproductive function in women has been found for lead. By interfering with normal hormone and endocrine function, endocrine disruptors contribute to the development of endometriosis and polycystic ovarian syndrome.

“Activities in the oil and gas industry can contaminate surface, ground and drinking water through the drilling process, hydraulic fracturing, failure in well casings, wastewater spills, and structural failure in abandoned wells. This has led to concerns about health risks to those exposed to the chemicals used and produced in the industry via either residential proximity or occupational exposure.”

Ashiru, who is also the Assistant Secretary-General International Federation of Fertility Societies (IFFS) and member, Reproductive and Developmental Environmental Health Committee (RDEH of FIGO), added: “Petrochemicals have been associated with adverse effects on the menstrual cycle and overall fecundity in women. The report of Kassotis et al reveals that many chemicals used in and produced by oil and gas operations can disrupt estrogen receptor, androgen receptor, and progesterone receptor. Ekpenyong et al and Webb et al reported that exposure to chemicals produced in oil and gas operations impaired menstrual cycle and fecundity.

“The fact that reproductive health hazards incurred by pro- longed exposure potentially have trans-generational effects causes great concern. Better understanding of the roles environmental toxins play on reproductive health may have significant impact on infertility management. The Mayr type of detoxification was employed for such patients as a complementary therapy.”

He added: We in Nigeria must find this to be very alarming. One cannot overemphasize the detrimental role that toxins play not only in the development of certain ailments like cancers and pulmonary pathologies, but also on our reproductive health.

Current experience in clinical practice amplifies this hazard, and it is particularly worrisome because there is no roburst program in our country that deals with the estimation or control of the various toxins released into the environment.

“Environmental toxins come in various forms like fumes from automobile and generator exhaust, diesel engines, industrial waste, etc.

As a result, there is substantial cross sectional variation in lead in topsoil. Lead in topsoil is re-suspended in a number of contexts, including dry or windy seasons, during construction, and when it is tracked into houses in the form of dust. For both airborne lead and lead in topsoil, exposure occurs through inhalation and consumption.

Consumption occurs when food or drink comes in contact with dust or if food is grown in lead-contaminated soil. In 2010, the World Health Organization stated that for the general population ‘the largest contribution to the daily intake of lead is derived from the ingestion of food, dirt and dust.’

“Fertility is important at both the individual and societal level, where it has implications for economic activity. Thus, factors that adversely affect fertility are of significant policy concern.

Animal studies and epidemiological research on workers with high occupational exposure have shown that lead can adversely affect both male and female reproductive systems. Whether these effects extend to fertility in the broader population, where exposure levels are lower, and the magnitude of any causal effects are open questions.”


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