Eating white button mushrooms may improve blood sugar control

A new study has found that eating white button mushrooms can affect glucose, or blood sugar, regulation, thereby reducing diabetes and other metabolic conditions, such as obesity.

The study, which was recently conducted to investigate the effects of white button mushrooms (Agaricus bisporus) as prebiotics, was carried out on mice by researchers working in various departments at Pennsylvania State University

The researchers wanted to see whether white button mushrooms could influence the production of glucose in the body, and how. Their findings, in a paper now published in the Journal of Functional Foods.Mushrooms alter the gut microbiome, showed that prebiotics, which are substances, often derived from the foods we ingest, supports the activity of microorganisms in the gut, and can boost the growth of beneficial bacteria.

In a mouse model, the scientists were able to map out how white button mushrooms modify the gut microbiota, ultimately leading to improved glucose regulation in the mice’s systems.The researchers worked with two types of mice: one with a regular gut microbiome, and one bred to lack a gut microbiome, which is entirely germ-free. The latter acted as the control group.

The researchers fed all the mice a daily serving of white button mushrooms, which is equivalent to about three ounces of mushrooms per day for humans.They found that the mice with gut microbiomes experienced changes in their populations of gut microbes. Their guts produced more short-chain fatty acids, such as propionate synthesized from succinate.

A co-author, Margherita Cantorna said, “Managing glucose better has implications for diabetes, as well as other metabolic diseases,” According to her, diabetes, our bodies do not produce enough of the hormone insulin, which helps regulate blood sugar levels, while the insulin helps transfer glucose from the blood and into the cells, to provide them with energy, which also places excess glucose “into storage,” so that it can be converted into energy as it is needed.

Cantorna and her colleagues believe that eating white button mushrooms triggers reactions in the gut microbiome that lead to the growth of certain types of bacteria, such as Prevotella, which, in turn, boosts the production of propionate and succinate.

These, the scientists explain, can alter the expression of certain genes that are involved in the production of glucose, also known as “glucogenesis.”“You can compare the mice with the microbiota with the germ-free mice to get an idea of the contributions of the microbiota,” says Cantorna. However, the findings suggest that white button mushrooms, as a prebiotic food, could be used in the future to manage diabetes, due to the role that they seem to play in glucogenesis.

While, the study was conducted in mice with a normal weight, the researchers explain that they are also interested in testing the effects of this prebiotic food in mice with obesity.This, they noted, would be the first step toward eventually extending this research to human participants, in the hope that it will lead to a better understanding of how our daily diets impact metabolic processes and influence the prevention or development of certain health conditions.