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Revolutionary treatment may prevent blindness

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Blindness


*Scientists discover way of boosting stem cells’ healing properties after eye injuries, acid attacks

Acid attack victims could be saved from blindness after a ‘revolutionary’ treatment, which has been tested by scientists. The pioneering method uses an enzyme, which prevents stem cells – blank cells, which can turn into new tissue – from losing their healing abilities in the eye following injury.Stem cells treat an injury to the eye, such as from acid burns, cuts or infection, by dividing and heading directly to the wound.

The development offers hope to almost 500,000 people across the world each year that lose their sight due to chemical burns.One of the most famous cases of this in the United Kingdom (UK) was that of TV personality Katie Piper who was attacked in 2008 and needed some of her sight restored.

Using live corneal tissues from an eye in a lab, researchers from Newcastle University and the University of Missouri, United States (U.S.), recreated the effects of chemical burns. They found stem cells could lose their healing properties when the tissue they’re contained in ‘stiffens’ after an injury. They found that using collagenase, a tissue-softening enzyme, could soften up the stiffened area. This, in turn, made it more able to support stem cells to promote healing.

The study authors described the research as being ‘a potential revolution’ in its field. The research was published in the journal Nature Communications.

Dr. Ricardo Gouveia said: “This study demonstrates a potential new way to treat injuries by changing the stiffness of the natural environment which we have shown changes the behaviour of the adult stem cells.”

When stem cells repair a damaged cornea they quickly divide in great numbers and become cells, which can make a solid membrane then move to the injury to seal it. However, this healing process can be compromised when injuries reach the stem cell niche – the area of tissue in the cornea where stem cells live.

The scientists found that stiffening the niche causes stem cells to mature and lose their self-renewing properties.
Professor Che Connon, from Newcastle University, said: “We can now prove that the cornea becomes stiffer when exposed to injuries such as those caused by what are commonly known as acid attacks.

“[We can] demonstrate that wound healing is impaired due to stem cells differentiating in response to the stiffening of their otherwise soft niche, and not because they are killed during injury, as previously thought. “This is an exciting development in the field of corneal biology, and allows us to better understand how vision works. “But even more important, it provides us with a new set of strategies to treat eye conditions which were until now inoperable.”

Both the US Food and Drug Administration and the European Medicine Agency have already approved the collagenase formulation for other purposes. The scientists said the findings are also promising for people suffering from blindness caused by corneal scarring from cuts or disease.

The cornea is a thin piece of tissue, which can be easily damaged by injury or infection, sometimes by contact lenses or a fingernail. More than 1.5 million new cases of corneal blindness are reported every year worldwide, and around 4,000 cornea transplants are done every year in the UK.Professor Connon said their study is even relevant to the research of cancer treatment, where tumour stiffening is a known marker of aggressive cancer cell behaviour.


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BlindnessRicardo Gouveia
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