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Stepping up efforts to tackle antimicrobial resistance


Director General, NAFDAC, Prof. Mojisola Christianah Adeyeye

• NAFDAC warns use of calcium carbide for fruit ripening could cause cancer, heart, kidney, liver failure
Worried that most disease may soon become untreated, countries including Nigeria are making significant steps in tackling antimicrobial resistance (AMR). But, according to a report released Tuesday by the Food and Agriculture Organization of the United Nations (FAO), World Organisation for Animal Health (OIE) and the World Health Organization (WHO), serious gaps remain and require urgent action.

Meanwhile, the National Agency for Food and Drug Administration and Control (NAFDAC) has warned that the dangerous practice of sale and consumption of fruits artificially ripened with calcium carbide may be the major cause of rising cases of sleeping disorders, mouth ulcers, skin rashes, kidney problems and possibly even cancer.

The AMR report published Tuesday by the WHO charts progress in 154 countries and reveals wide discrepancies. Some, including many European countries, have been working on AMR policies in human and animal sectors for more than four decades. Others have only recently started to take action to contain this growing threat. Progress in developing and implementing plans is greater in high-income than low-income countries but all countries have scope for improvement. No country reports sustained capacity at scale in all areas.


The report looks at surveillance, education, monitoring and regulating consumption and use of antimicrobials in human health, animal health and production, as well as plants and the environment – as recommended in the Global Action Plan published in 2015.

Promising findings include 105 countries with a surveillance system in place for reporting drug-resistant infections in human health and 68 countries with a system for tracking consumption of antimicrobials. In addition, 123 countries reported that they have policies to regulate the sale of antimicrobials, including the requirement of a prescription for human use – a key measure to tackle overuse and misuse of antimicrobials.

But implementation of these policies varies and unregulated medicines are still available in places such as street markets, with no limits on how they are used. Medicines are very often sold over the counter and no prescription is requested. This puts human and animal health at risk, potentially contributing to the development of antimicrobial resistance.

Director General of NAFDAC, Prof. Moji Adeyeye, in a statement on the health hazards of consuming fruits ripened with calcium carbide, said calcium carbide when sprayed with water reacts chemically to produce acetylene, which acts like ethylene and ripens fruits by a similar process. Adeyeye said calcium carbide generally contains impurities such as arsenic, lead particles, phosphorus, etc., that pose a number of very serious health hazards.She explained: “These impurities may cause serious health problems when those applying calcium carbide on fruits come in direct contact with the chemical.

“Consumption of fruits containing these impurities may cause cancer, heart, kidney and liver failure.“They may cause frequent thirst, irritation in mouth and nose, weakness, permanent skin damage, difficulty in swallowing, vomiting, skin ulcer and so forth.

“Higher exposure may cause undesired fluid build-up in lungs (pulmonary oedema). “Acetylene produced by Calcium Carbide affects the neurological system and reduces oxygen supply to the brain and further induces prolonged hypoxia. “The impurities are hazardous to pregnant women and children and may lead to headache, dizziness, mood disturbances, mental confusion, memory loss, cerebral oedema (swelling in the brain caused by excessive fluids), sleepiness, seizure etc.

“Calcium Carbide is alkaline in nature and erodes the mucosal tissue in the abdominal region and disrupts intestinal functions. “Consuming such artificially ripened fruits could result in sleeping disorders, mouth ulcers, skin rashes, kidney problems and possibly even cancer.

“Other symptoms of poisoning include diarrhoea (with or without blood), burning or tingling sensation in abdomen and chest difficulty in swallowing, irritation in eyes/skin, sore throat, cough, shortness in breathing, numbness etc.”

Meanwhile, the report highlights areas, particularly in the animal and food sectors, where there is an urgent need for more investment and action. For example, only 64 countries report that they follow FAO-OIE-WHO recommendations to limit the use of critically important antimicrobials for growth promotion in animal production. Of these, 39 are high-income countries, with the majority in WHO’s European Region. By contrast, only three countries from WHO’s African Region and seven countries from the WHO Region of the Americas have taken this important step to reduce the emergence of antimicrobial resistance.


A total of 67 countries report at least having legislation in place to control all aspects of production, licensing and distribution of antimicrobials for use in animals. But 56 either said that they had no national policy or legislation regarding the quality, safety and efficacy of antimicrobial products used in animal and plant health, and their distribution, sale or use, or that they were unable to report whether they have these policies in place.

There is also a substantial lack of action and data in the environment and plant sectors. Although 78 countries have regulations in place to prevent environmental contamination generally, only 10 of them report having comprehensive systems to ensure regulatory compliance for all waste management, including regulations that limit the discharge of antimicrobial residues into the environment. This is insufficient to protect the environment from the hazards of antimicrobial production.

“This report shows growing global momentum to combat antimicrobial resistance,” says Dr. Ranieri Guerra, Assistant Director-General for Antimicrobial Resistance at WHO. “We call on governments to make sustained commitments across all sectors – human and animal health, plant health and the environment – otherwise we risk losing the use of these precious medicines.”

“Supporting low- and middle-income countries to follow guidance of responsible and prudent use of antimicrobials in animals is an urgent priority,” says Dr. Matthew Stone, Deputy Director General of the World Organisation for Animal Health (OIE). “Implementation of dedicated OIE international standards, appropriate national legislation and strengthening of veterinary services are essential steps to help all animal health stakeholders contribute to controlling the threat posed by antimicrobial resistance.”

“FAO welcomes that many countries are taking concrete steps towards the responsible use of antimicrobials in agriculture,” says Maria Helena Semedo, FAO Deputy Director-General. “However, countries need to do more to reduce the unregulated and excessive use of antimicrobials in agriculture. We particularly urge countries to phase out the use of antimicrobials for growth promotion in animal production – terrestrial and aquatic.”

From this survey and other sources, the Tripartite (FAO, OIE and WHO) is aware that 100 countries now have national action plans for AMR in place and a further 51 countries have plans under development, but more needs to be done to ensure that they are implemented. Only 53 countries report that they have a multisectoral-working group that is fully functional, although a further 77 have established such a group. Only 10 countries report that the funding for all actions in the plan is identified and many middle- and low-income countries may need long-term development assistance to implement their plans effectively and sustainably. Positively, among the top ten chicken-, pork- and cattle-producing countries that responded to the AMR survey, 9 out of 10 have at minimum developed a national action plan; the majority of these have plans in operation with a monitoring arrangement.

The global tripartite survey of country progress in addressing AMR is part of monitoring implementation of the Global Action Plan on AMR, which was endorsed by WHO and FAO Member States, and OIE Member Countries in 2015.The survey is developed and issued jointly by the three Organizations and the report analyses the data from year two of the survey.The 2018 survey received responses from 154 countries (out of 194 of WHO Member States contacted). All countries’ responses from both years are published in an open-access database, offering scope for in-country review with civil society and other stakeholders.


Meanwhile, the NAFDAC DG warned farmers’ traders and the general public that ripening fruits with calcium carbide is very dangerous to health and is a criminal offence, and that perpetrators would be prosecuted.

She said NAFDAC is commencing immediate nationwide monitoring of fruits markets to check activities of unscrupulous traders involved in illegal artificial ripening of fruits using hazardous chemicals such as calcium carbide.

“Consumers are advised to examine fruits carefully to select the right fruit by observing the variation of colour. If the fruit that you buy is too good among others in “near perfect” ripening color, it may have been ripened with calcium carbide. Fruits should be washed thoroughly under running water before consumption.“The public is advised to report suspected cases to the nearest NAFDAC office or call 09094262773, 09094262772 and 08133630600.”

In this article:
Moji AdeyeyeNAFDAC
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