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New platform aims to provide safe, effective cancer medicines to approximately 120,000 children between 2022 and 2027

By Chukwuma Muanya
14 February 2022   |   3:38 am
The World Health Organisation (WHO) and St. Jude Children’s Research Hospital on Monday announced plans to establish a platform that will dramatically increase access to childhood cancer medicines

World Health Organization (WHO) Director-General Tedros Adhanom Ghebreyesus gives a press conference on December 20, 2021 at the WHO headquarters in Geneva. – The World Health Organization chief called for the world to pull together and make the difficult decisions needed to end the Covid-19 pandemic within the next year. (Photo by Fabrice COFFRINI / AFP)

The World Health Organisation (WHO) and St. Jude Children’s Research Hospital on Monday announced plans to establish a platform that will dramatically increase access to childhood cancer medicines around the world. The Global Platform for Access to Childhood Cancer Medicines, the first of its kind, will provide an uninterrupted supply of quality-assured childhood cancer medicines to low- and middle-income countries. St. Jude is making a six-year, US$ 200 million investment to launch the platform, which will provide medicines at no cost to countries participating in the pilot phase. This is the largest financial commitment for a global effort in childhood cancer medicines to date.

WHO Director-General Dr. Tedros Adhanom Ghebreyesus, said: “Close to nine in ten children with cancer live in low- and middle-income countries. Survival in these countries is less than 30 per cent, compared with 80 per cent in high-income countries. This new platform, which builds on the success of the Global Initiative for Childhood Cancer launched with St. Jude in 2018, will help redress this unacceptable imbalance and give hope to many thousands of parents faced with the devastating reality of a child with cancer.” Each year, an estimated 400,000 children worldwide develop cancer. The majority of children living in low- and middle-income countries are unable to consistently obtain or afford cancer medicines. As a result, nearly 100,000 children die each year.

The new platform aims to provide safe and effective cancer medicines to approximately 120,000 children between 2022 and 2027, with the expectation to scale up in future years. This platform will provide end-to-end support ̶ consolidating global demand to shape the market; assisting countries with the selection of medicines; developing treatment standards; and building information systems to track that effective care is being provided and to drive innovation. President and Chief Executive Officer (CEO) of St. Jude, Dr. James R. Downing, said: “St. Jude was founded on the mission to advance research and treatment of childhood cancer and other catastrophic pediatric diseases. Nearly 60 years later, we stand with the World Health Organization, partner organizations and our Global Alliance collaborators to expand that promise for children worldwide. With this platform, we are building the infrastructure to ensure that children everywhere have access to safe cancer medicines.”

This innovative approach will open a new chapter in access to cancer care by addressing medicine availability in low- and middle-income countries that is often complicated by higher prices, interruptions in supply and out-of-pocket expenditures that result in financial hardship.

According to a WHO Non communicable Disease Country Capacity survey published in 2020, only 29 per cent of low-income countries report that cancer medicines are generally available to their populations compared to 96 per cent of high-income countries. By consolidating the needs of children with cancer globally, the new platform will curtail the purchasing of sub-standard and falsified medicines that results from unauthorized purchases and the limited capacity of national regulatory authorities.

Executive vice president and chair of the St. Jude Department of Global Pediatric Medicine and director of St. Jude Global, Carlos Rodriguez-Galindo, said: “Unless we address the shortage and poor quality of cancer medicines in many parts of the world, there are very few options to cure these children.

“Health-care providers must have access to a reliable source of cancer medicines that constitute the current standard of care. We at St. Jude, with our co-founding partners at WHO and many vital partners around the world, can help achieve that.”

Director of the Department of Non communicable Diseases at WHO, Dr. Bente Mikkelsen, said: “WHO, St Jude and partners will spare no efforts to get children’s access to cancer medicines on track. WHO is on the ground, working with governments to deliver support and services to ensure that all children have access to the best cancer treatment possible.”

During an initial two-year pilot phase, medicines will be purchased and distributed to 12 countries through a process involving governments, cancer centers and nongovernmental organizations already active in providing cancer care. Discussions are already ongoing with governments to determine the countries, which will participate in this pilot phase. By the end of 2027, it is expected that 50 countries will receive childhood cancer medicines through the platform.

President of the International Society of Paediatric Oncology, Kathy Pritchard-Jones, said: “We look forward to working with St. Jude and WHO on this journey to ensure all children, everywhere, have access to quality cancer medicines. The platform is bringing forth a dream of our more than 2600 global members.”

President of Childhood Cancer International, João Bragança, added: “Cancer should not be a death sentence, no matter where a child lives. By developing this platform, St. Jude is helping families get access to lifesaving medicines for their children. Working together, we can change the outcome for cancer-afflicted children around the world.”

The World Health Organization and St. Jude Children’s Research Hospital first collaborated in 2018, when St. Jude became the first WHO Collaborating Centre for Childhood Cancer and committed US$ 15 million for the creation of the Global Initiative for Childhood Cancer. This Initiative supports more than 50 governments in building and sustaining local cancer programmes and aims to increase survival to 60 per cent by 2030.The platform synergizes with the Global Initiative, with activities implemented through this new effort expected to contribute substantially to the achievement of the Initiative’s goals.

The Global Platform for Access to Childhood Cancer Medicines is part of the Six-Year St. Jude Strategic Plan focused on accelerating progress on catastrophic childhood diseases on a global scale through the institution’s largest investment in research and patient care.

Dedicated to the well being of all people and guided by science, the World Health Organization (WHO) leads and champions global efforts to give everyone, everywhere an equal chance at a safe and healthy life. WHO is the UN agency for health that connects nations, partners and people on the front lines in 150+ locations – leading the world’s response to health emergencies, preventing disease, addressing the root causes of health issues and expanding access to medicines and health care. WHO’s mission is to promote health, keep the world safe and serve the vulnerable.

With respect to childhood cancer, WHO works with more than 100 global partners to support governments, through the Global Initiative for Childhood Cancer, to develop high-quality cancer centres and regional satellites that ensure early and accurate diagnosis and effective treatment for children with cancer. WHO also develops standards and tools to guide the planning and implementation of interventions for early diagnosis, treatment and palliative and survivorship care.

St. Jude Children’s Research Hospital in Memphis, Tennessee, USA, is a global leader in the research and treatment of childhood cancer and other life-threatening pediatric diseases. St. Jude is the only National Cancer Institute–designated Comprehensive Cancer Center devoted solely to children. Treatments developed at St. Jude have helped push the U.S. childhood cancer survival rate from 20 per cent to 80 per cent since the hospital opened in 1962. St. Jude is extending its mission to help more children around the world. In 2018, St. Jude and the World Health Organization launched the Global Initiative for Childhood Cancer to increase survival rates to 60 per cent by 2030 for the most common forms of childhood cancer. The St. Jude Global Alliance is a global network with a shared vision of improving care and increasing survival rates of children with cancer and blood disorders worldwide.

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