Tasnim Olatoke: Nigerian researcher revolutionising fight against rare lung disease

In a groundbreaking achievement that is reverberating across the global scientific community, Tasnim Olatoke, a Nigerian-born researcher, is making waves in the United States with her pioneering research on Lymphangioleiomyomatosis (LAM)—a rare and progressive lung disease that predominantly affects women of childbearing age. Currently pursuing her PhD in Pharmacology and Physiology at the University of Cincinnati, Tasnim’s innovative findings are revolutionizing the treatment landscape for this devastating condition.

LAM, which is characterized by the infiltration of abnormal cells into the lungs, leads to tumor formation, breathing difficulties, and, ultimately, life-threatening complications. Until recently, the origin of these cells and the mechanisms driving their invasion into lung tissue remained poorly understood. However, through meticulous research leveraging advanced single-cell RNA sequencing, Tasnim and her team identified a novel pathway linking the disease’s pathogenesis to uterine signaling circuits. This discovery opens the door to a completely new therapeutic approach for LAM, offering hope to thousands of patients worldwide.

Tasnim’s research, published as a lead author in the prestigious journal Science Advances, provides evidence for targeting the HOX-PBX1 gene network, a critical regulatory pathway in LAM’s progression. Her team also demonstrated that disrupting this pathway using an experimental drug effectively halts the survival of tumor cells in laboratory and animal models. Through treating cells derived from LAM patients, they observed significant reductions in tumor growth and lung colonization—results that represent the first evidence-backed proof of the disease’s uterine origin.

For Tasnim, the most rewarding aspect of her research has been engaging with LAM patients and collaborating with scientists across institutions. “LAM patients are an extraordinary community—resilient, empathetic, and deeply supportive of the research that could one day change their lives,” Tasnim shared. She also emphasized the power of collaboration, citing the contributions of investigators from the University of Cincinnati, Cincinnati Children’s Hospital, and Texas Tech University as instrumental in driving the project forward.

A graduate of Osun State University, where she earned her bachelor’s degree in Physiology, Tasnim has always been passionate about contributing to science in ways that make a tangible difference. Before moving to the U.S., she honed her skills as a research assistant in Nigeria, exploring the biochemical and reproductive impacts of substances such as Tramadol and traditional medicinal plants. Her curiosity and dedication to unraveling complex biological mechanisms have remained steadfast throughout her academic and professional journey.

In addition to her scholarly pursuits, Tasnim has been recognized with numerous accolades, including top honors at international conferences such as the American Thoracic Society and the International TSC Research Conference. Her publication has also garnered attention from leading experts in the field.

Beyond the lab, Tasnim is also a fierce advocate for diversity in science, mentoring young women and underrepresented groups to pursue careers in biomedical research. “My goal is not just to advance research but to inspire others to see the possibilities of science and its power to change lives,” she said.

As Tasnim continues her work on LAM and related conditions, her efforts exemplify the profound impact that innovative research and global collaboration can have. For Nigeria, her achievements are a testament to the country’s growing pool of world-class scientists who are making significant contributions on the global stage. For the world, her work represents a ray of hope in the fight against rare diseases.

Tasnim’s journey serves as a reminder that with dedication, ingenuity, and collaboration, the most complex medical challenges can be met with solutions that bring healing and hope.