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Scientists engineer mosquitoes that can’t spread disease

By Chukwuma Muanya
23 September 2022   |   4:10 am
Scientists have engineered mosquitoes that slow the growth of malaria-causing parasites in their gut, preventing transmission of the disease to humans.

Scientists have engineered mosquitoes that slow the growth of malaria-causing parasites in their gut, preventing transmission of the disease to humans.

Researchers from the Transmission:Zero team at Imperial College London demonstrated how genetic modification causes mosquitoes to produce compounds in their guts that stunt the growth of parasites, meaning they are unlikely to reach the mosquitoes’ salivary glands and be passed on in a bite before the insects die.

The results of the modification technology in the lab and the modelling were published, yesterday, in the journal Science Advances.

So far, the technique has been shown to dramatically reduce the possibility of malaria spread in a lab setting. But if proven safe and effective in real-world settings, it could offer a powerful new tool to help eliminate malaria.

The innovation is designed so it can be coupled with existing ‘gene drive’ technology to spread modification and drastically cut malaria transmission. The team is looking towards field trials, but will thoroughly test the safety of the new modification before combining it with a gene drive for real-world tests.

Collaborators from the Institute for Disease Modeling at the Bill and Melinda Gates Foundation also developed a model that, for the first time, can assess the impact of such modifications, if used in a variety of African settings.

They found that the modification developed by the Transmission: Zero team could be a powerful tool for bringing down cases of malaria even where transmission is high.