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The cause of death was cardiorespiratory arrest associated with a cardiac arrhythmia, his club Nacional announced, citing the doctors treating him at the Albert Einstein Hospital in São Paulo, Brazil.
Izquierdo died at 9:38 pm on Tuesday evening (0038 GMT Wednesday).
The centre-back collapsed in the 84th minute of the second leg of the round of 16 tie against São Paulo FC last Thursday.
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Izquierdo’s death was an “irreparable loss,” Nacional said in a post on social media platform X.
The head of South American football association CONMEBOL, Alejandro Domínguez, expressed his condolences to Izquierdo’s club and his family.
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“South American football is in mourning,” he said.
Izquierdo made his debut in Uruguay’s first division with Club Atlético Cerro in 2018.He moved to Nacional in 2022.
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During his time there he played 33 games and scored two goals.
São Paulo won the game 2-0 last Thursday and progressed to the quarter-finals of the Copa Libertadores.
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